Fenbendazole + Praziquantel Tablets

Active Ingredients: Fenbendazole, Praziquantel

Fenbendazole + Praziquantel Tablets are a broad-spectrum dewormer drug used to treat or control gastrointestinal roundworms and tapeworms. It is typically used to treat dogs and cats, but may be used for other animals. This combination is an effective treatment for a wide range of parasites.

This combination contains two active ingredients: Fenbendazole and Praziquantel. The combination shows nematicidal activity and is also active against imaginal and larval stages of parasites.

Fenbendazole is classified as a benzimidazole carbamate. It shows a broad spectrum of activity against both mature and immature nematodes and cestodes. Fenbendazole works by inhibiting glucose uptake. This drains a parasite's glycogen reserves, which leads to its death. Fenbendazole produces an ovicidal effect. It is also noted that this drug has a wide safety margin. Among benzimidazoles, it has the longest half-life, ensuring effective plasma and gut concentrations over an extended period. This prolonged presence enhances its efficacy against immature, arrested larvae, and adult nematodes. Its efficacy is significant in ruminants due to slow passage through the rumen. Administering the drug at intervals of 12 hours increases contact time and improves bioavailability, enhancing its effectiveness. Metabolites are primarily eliminated through the biliary pathway with enterohepatic recycling.

Praziquantel is a pyrazine isoquinoline derivative. This compound causes severe damage to the parasites integument, which results in the contraction and paralysis of the parasites. Praziquantel is effective against trematodes and tapeworms, including Toxocara canis, Toxascaris leonina, Uncinaria stenocephala, Ancylostoma caninum, and Trichuris vulpis. It is also effective against cestodes, including Dipylidium caninum, Taenia, and Echinococcus granulosus. This medication disrupts parasites' energy metabolism by lowering their ability to generate energy through phosphorylation. Following oral administration, it is absorbed slowly and incompletely from the gastrointestinal tract. It distributes throughout the body, achieving therapeutic concentrations at infection sites. The drug is primarily excreted via bile into feces, with minimal amounts excreted in urine.

AdvaCare Pharma is a trusted global producer and exporter of Fenbendazole + Praziquantel Tablets. This veterinary medication is manufactured under strict GMP regulations in our facilities in China, India, and the USA.

Fenbendazole + Praziquantel Tablets, manufactured and globally supplied by AdvaCare Pharma, are one of our 250+ veterinary medicines. From supply chain coordination to product registration support, our professional teams of specialists and experts provide our veterinary distributors unparalleled support. As a trusted Fenbendazole + Praziquantel Tablets manufacturer, veterinarians and farmers alike rely on our high-quality veterinary tablets manufactured according to GMP standards.

What is Fenbendazole + Praziquantel used for?

What animals can be treated with Fenbendazole + Praziquantel Tablets?

This medicine is recommended for cats and dogs.

How are Fenbendazole + Praziquantel Tablets used?

This medicine has been manufactured as a tablet which is intended to be given orally to an animal. This drug can be given directly to the dog or disguised in food. No specific feeding regime or starvation is needed. For routine deworming, only a single treatment is necessary. The treatment should be repeated every three months for routine worm control. In cases of heavy roundworm infestations, a repeated dose should be given. The dose should be determined by a veterinarian and it is based on the animal’s body weight.

How do Fenbendazole + Praziquantel Tablets help animals?

Fenbendazole + Praziquantel Tablets help animals by causing severe damage to the parasite integument, which results in contraction and paralysis of the parasite (Praziquantel). Fenbendazole prevents the formation of microtubules which results in the disruption of structures vital to normal helminth functioning.

Are Fenbendazole + Praziquantel Tablets effective in the treatment of bacterial infection?

No, this is a drug that is effective only in the treatment of parasitic infections. In cases of bacterial infections, antibiotics need to be included.

Can Fenbendazole + Praziquantel Tablets be used for treating viral infections?

No, Fenbendazole + Praziquantel Tablets are not effective in the treatment procedure of viral infections. In cases of viral infections, antiviral drugs, vitamins, and other supplements need to be included.

Does Fenbendazole + Praziquantel Tablets help in managing schistosomiasis?

Fenbendazole + Praziquantel Tablets are a cost-effective choice for treating schistosomiasis in dogs. Lower doses of Praziquantel and Fenbendazole can eliminate asymptomatic infections. One study included 12 asymptomatic dogs with positive fecal saline sedimentation and fecal PCR. On day 60 of the treatment procedure, all 12 dogs were negative by fecal saline sedimentation, and 8 of 12 dogs were negative on fecal PCR. The 3 dogs that remained positive were re-treated and they all became negative on the test results. The conclusion of this study is that a low dose of Praziquantel and Fenbendazole can be effective in the treatment of asymptomatic schistosomiasis in dogs.

Which clinical signs can be treated with Fenbendazole + Praziquantel Tablets?

Fenbendazole + Praziquantel is an antiparasitic drug and can help in solving the symptoms that arise from these infections. It targets signs like lethargy, weight loss, diarrhea, colic, lack of appetite, and dull coat. It can also improve the results of the blood tests and biochemical parameters.

Can Fenbendazole + Praziquantel Tablets be used for other animals?

Yes, this drug is often given to livestock and other animals that have parasitic infections. However, this product specifically targets companion animals (cats and dogs). It should be consulted with a veterinarian if this drug can be efficient in treating parasitic infections in livestock.

Can Fenbendazole + Praziquantel Tablets be used in pregnant animals?

Fenbendazole + Praziquantel Tablets should not be used in pregnant animals before the 39th day of pregnancy. The recommended dose should be followed. It should be used only when the benefits outweigh the risks because there is not enough scientific evidence about the drug’s safety regarding the teratogenic effects.

What should be done if a dose is missed?

If a dose of this drug is missed, the next scheduled dose needs to be given. Do not give double doses of this drug.

How should Fenbendazole + Praziquantel Tablets be stored?

This medication should be stored in a dark, dry location below 25°C. Keep the tablets in the blister pack when not in use.

What is the usual dose of Fenbendazole + Praziquantel Tablets?

For prevention as a routine treatment, only one treatment is necessary. Treatments should be done quarterly. For a serious infestation, the duration of treatment is one dose per day for 3 days.

Refer to a veterinary doctor or pharmacist for guidelines on dosage.

As with all pharmaceuticals, some unwanted effects can occur from the use of Fenbendazole + Praziquantel Tablets.

Common side effects include loss of appetite, diarrhea, vomiting, excessive salivation, and fatigue. Crying and restlessness in puppies can also occur. Serious side effects may include allergy or hypersensitivity reactions. If any side effects arise it should be reported to a veterinarian as soon as possible.

For a comprehensive list of all possible side effects of this medication, consult a veterinarian.

Follow the recommended dosage from the veterinarian. Accidental overdosing should be managed as soon as possible if it leads to side effects.

Keep good hygiene practices when giving this supplement. This will prevent parasites from spreading around the animal’s environment. Once cured, animals can get infected again if their environment is infested with parasites from bad environmental hygiene.

If you miss a dose, do not give two doses at once.

This drug should not be used in puppies and kittens under 3 weeks of age. It also should not be used in pregnant animals under 39 days. All medicinal products need to be used with caution in pregnant animals and should only be used when the benefits outweigh the risks and when clearly needed.

The dosage in patients with renal or hepatic impairment should be determined carefully.

Fenbendazole + Praziquantel Tablets are mainly used to treat gastrointestinal tapeworms and roundworms.

Companion Animals Parasitic Infections

This drug is largely used for treating ascarids in dogs like Toxocara canis and Toxascaris leonina (adult and late immature forms). It is also used for treating hookworms like Uncinaria stepcephala, Ancylostoma caninum (adults), whipworms like Trichuris vulpis (adults), tapeworms like Echinococcus spp., Taenia spp., Dipylidium caninum (adult and immature forms).