Avermectin Pour-On Solution

Active Ingredients: Avermectin

Avermectin Pour-On Solution is a dewormer drug used to treat and control parasites in cows. It is indicated for the treatment and prevention of nematodes such as grubs, sucking lice, and mange mites. Depending on the infection, it may be necessary to combine this external treatment with an internal dewormer.

Avermectin is within the family of medicines called anthelmintics. It is derived from Streptomyces avermitilis fermented products. Avermectin works by inhibiting the function of aspects of the nervous system within the parasite, leading to their paralysis and eventual death.

Once applied, the drug binds selectively and with high affinity to glutamate-gated chloride ion channels, which are prevalent in invertebrate nerve and muscle cells. This binding causes an increase in the permeability of the cell membrane to chloride ions, resulting in hyperpolarization of the nerve or muscle cell and paralysis and death of the parasite.

This effect is specific to parasites and does not affect mammals, including cows, as these glutamate-gated chloride channels are not present in their nervous systems.

Avermectin has a broad spectrum of activity against internal and external parasites. Its efficacy in treating infections such as gastrointestinal roundworms, lungworms, and liver flukes is significant. For external parasites like mites, lice, and ticks, the drug disrupts their normal feeding and reproductive behaviors, leading to their gradual elimination from the animal.

The longevity of its effect is another advantage, as it continues to work for several weeks after a single application, providing long-term protection against re-infestation. When used as part of an integrated pest management program, Avermectin can significantly reduce the parasite burden in a herd.

Avermectin Pour-On Solution should never be used on humans, as its formulation and dosage are specifically tailored for cattle and can be harmful if misapplied. When handling and applying this product, use appropriate protective gear to prevent direct skin contact, inhalation, or accidental ingestion.

Avermectin Pour-On Solution is manufactured and produced by AdvaCare Pharma, a pharmaceutical company specializing in global distribution. Our focus on quality has made AdvaCare a market leader in many countries. We offer a broad range of high-quality, cost-effective veterinary medications available for exportation.

AdvaCare Pharma is a leading GMP-certified manufacturer of Avermectin Pour-On Solution. We manufacture a wide range of over 250+ veterinary medicines, including 70+ liquid formulations, to meet the needs of veterinary distributors worldwide. From supply chain coordination to document and registration support, we offer unbeatable assistance throughout the entire process.

What is Avermectin used for?

What animals can be treated with Avermectin Pour-On Solution?

It's recommended for cows.

How is Avermectin Pour-On Solution used?

This medication has been manufactured as a liquid, which is packaged in a bottle. It is intended to be administered topically. Avermectin Pour-On Solution is intended for veterinary use only. For total parasite control, it is recommended to use this drug alongside other anthelmintic treatments for certain parasitic infections.

What is the withdrawal period for Avermectin?

The withdrawal period is 31-49 days for meat. The exact duration will depend on local regulations.

Can Avermectin Pour-On Solution be used during pregnancy or lactation in cattle?

The use of Avermectin Pour-On Solution in pregnant or lactating cattle should be approached with caution. While studies have shown no adverse effects on pregnant cows or their calves, consult a veterinarian before use.

Is Avermectin Pour-On Solution effective against all types of parasites in cattle?

The drug is effective against a broad range of parasites, including gastrointestinal roundworms, lungworms, cattle grubs, sucking lice, and mites, but it may not be effective against all types or stages. This medication may be used better as part of a comprehensive parasite control program.

How long does it take for Avermectin Pour-On Solution to start working?

The drug begins working soon after application. Most parasites are effectively controlled within 24 to 48 hours, but the total time for complete parasite eradication can vary based on the type of parasite and the severity of the infestation.

What should I do if Avermectin Pour-On Solution comes into contact with human skin or is ingested accidentally?

In case of accidental contact with human skin, wash the area thoroughly with soap and water. If ingested, seek medical attention immediately. The drug is for veterinary use only and can be harmful if accidentally exposed to humans.

Is there any resistance to Avermectin Pour-On Solution in parasites?

Parasite resistance can occur with repeated and improper use. To reduce the risk of resistance, use the product as directed and integrate it into a broader parasite management program.

Are there any special handling instructions for Avermectin Pour-On Solution?

When handling the medication, wear protective gloves and clothing to avoid skin contact. Avoid inhalation and direct contact with eyes and skin. Wash hands thoroughly after handling and before eating, drinking, or smoking. Store the product away from food and drink to prevent contamination.

Can Avermectin Pour-On Solution be used in other animals besides cattle?

The drug is primarily formulated for use in cattle and its safety and effectiveness in other animal species have not been thoroughly established. Using it in animals other than cattle could be harmful, as different species can react differently to medications. For instance, certain formulations of avermectin and related compounds (like ivermectin) are known to be toxic to some dog breeds and other animals.

How should Avermectin Pour-On Solution be stored?

This medication should be stored in a dark, dry location between 15-25°C. The bottle should be sealed tightly during storage. Keep the bottle flat when not in use.

How much Avermectin Pour-On Solution should be used on cattle?

The usual dose is 0.1ml per 1kg of body weight. This medicine should be applied in a narrow strip along the dorsal top-line of the animal.

Can the dosage of Avermectin Pour-On Solution be adjusted for smaller or larger cattle?

Yes, the dosage can be adjusted according to the weight of the cattle. Always maintain the recommended ratio of 0.1ml per 1kg of body weight, regardless of the size of the animal. For accurate dosing, weigh the animal or use an estimated weight based on breed standards.

Is it safe to repeat the treatment, and if so, after how long?

Avermectin Pour-On Solution can be repeated if necessary but it is typically advised to wait at least 28 days before reapplying.

What should I do if I accidentally administer an overdose?

In case of an accidental overdose, monitor the animal closely for any adverse reactions. Contact a veterinarian immediately as it may increase the risk of side effects.

Refer to a veterinary doctor or pharmacist for guidelines on dosage.

As with all pharmaceuticals, some unwanted effects can occur from the use of Avermectin Pour-On Solution.

If any of the mentioned side effects occur, discontinue the use of Avermectin immediately and seek veterinary care. For allergic reactions, antihistamines or corticosteroids might be prescribed. In cases of shock or neurotoxicity, supportive care, including intravenous fluids and monitoring of vital signs, may be necessary.

For a comprehensive list of all possible side effects of this medication, consult a veterinarian.

Administer the product in a well-ventilated area. Wear protective gloves and clothing while handling this product, and thoroughly wash your hands after application.

Avermectin is toxic to fish and other aquatic life due to its mode of action on neurological systems, which is not specific to just parasites but can also affect other invertebrates. When Avermectin enters aquatic ecosystems, either through runoff or improper disposal, it can disrupt the nervous systems of various aquatic organisms. This disruption can lead to paralysis and death in sensitive species.

Do not use it in ponds or other bodies of water. Dispose of any waste material according to local regulations. Careful handling and disposal of Avermectin are essential to prevent environmental contamination and protect aquatic life.

Avermectin Pour-On Solution is most commonly used in cattle, including both beef and dairy breeds: - Cows (Cattle): In cows, it serves as an effective treatment and control for a variety of internal and external parasites, such as gastrointestinal roundworms, lungworms, grubs, sucking and biting lice, and mites. The solution is particularly valued for its broad-spectrum activity and ease of application, typically administered along the cow's backline. It helps in improving the overall health and productivity of the cattle by effectively managing parasite loads.