Albendazole + Oxyclozanide Oral Suspension

Active Ingredients: Albendazole, Oxyclozanide

Albendazole + Oxyclozanide Oral Suspension is an anthelmintic drug used for treating and controlling parasitic infections due to roundworms, lungworms, tapeworms, amphistomes, and liver flukes in cows, goats, sheep, and pigs. It's also used for the control of Fascioliasis and Paramphistomiasis and is effective against Moniezia tapeworm segments.

The combination of Albendazole and Oxyclozanide is an effective treatment for both adult and larval stages.

Albendazole belongs to the drug class called benzimidazole anthelmintics. It exhibits broad-spectrum action against many varieties of worms, such as roundworms, tapeworms, and flukes of domestic animals and humans. The active ingredient works by inhibiting tubulin polymerization. As an effect, the worm's ability to utilize glucose is impaired, which results in immobilization and death.

The medication effectively kills adult worms, but the eggs can survive for several weeks after treatment, potentially requiring additional rounds. Albendazole is primarily used for nematodes and trematodes in domestic animals; its effectiveness against cestodes is limited. It provides a broad safety margin and acts broadly against roundworms. The absorption of this drug varies depending on factors such as species, formulation, dosage, solubility, and the esophageal groove reflex.

Benzimidazoles, which are mostly water-insoluble, are absorbed in the gastrointestinal tract with varying efficiency across different animal species. After absorption, this drug undergoes metabolic processes in the liver before being distributed throughout the body and eventually eliminated via feces and urine. Ruminants benefit notably from Albendazole due to its slow passage through the rumen.

Albendazole is recognized among benzimidazoles for its high effectiveness and extended half-life. While it successfully eliminates worms, eggs may survive for several weeks after treatment, potentially necessitating repeated treatments. This drug does not help in the treatment process of external parasites.

Oxyclozanide is a salicylanilide anthelmintic. It works by uncoupling oxidative phosphorylation. This drug is used primarily to control fascioliasis in ruminants. It is a proton ionophore and acts as a specific uncoupler of mitochondrial oxidative phosphorylation. It also works by disrupting the metabolism of the parasite. Its chemical structure consists of an unstable proton. This compound contains a lipophilic molecule that allows the passage of protons across membranes, especially through the inner mitochondrial membrane. It is efficient against the adult stage of Fasciola hepatica, but the efficacy against cestodes is limited.

This drug is slowly absorbed after oral administration and the peak plasma concentration is observed 13 hours after administration. The excretion of this drug is by fecal with biliary excretion. Feces on the pasture that contain this drug can reduce the abundance of dung-feeding organisms which aids in dung degradation. This drug persists in soils.

It is important to note that Albendazole + Oxyclozanide Oral Suspension is for veterinary purposes only. This formulation is intended to be prescribed by a veterinary doctor or animal care specialist for an animal.

AdvaCare Pharma is a GMP-certified manufacturer and exporter of Albendazole + Oxyclozanide Oral Suspension. We offer a wide range of high-quality and cost-effective livestock medications that are available for distribution. These medications have been produced in our facilities in China, India, and the USA.

AdvaCare Pharma is a GMP-certified manufacturer of Albendazole + Oxyclozanide Oral Suspension for veterinary use. To ensure that our products meet and exceed our distributors' standards, we conduct routine internal and third-party facility inspections. As an experienced Albendazole + Oxyclozanide manufacturer, our highly skilled team of professionals offers comprehensive support that extends throughout the entire process, including document and registration assistance.

What is Albendazole + Oxyclozanide used for?

What animals can be treated with Albendazole + Oxyclozanide Oral Suspension?

This medicine is recommended for livestock like cows, goats, pigs, and sheep. Do not use Albendazole to treat birds like pigeons or doves.

How is Albendazole + Oxyclozanide Oral Suspension used?

This medicine has been manufactured as a liquid, which is intended to be administered orally.

Can pregnant or lactating animals be treated with Albendazole + Oxyclozanide Oral Suspension?

This drug can be used for pregnant or lactating animals, but care should be taken in treating heavily pregnant animals and animals under stressful circumstances. This includes poor weather conditions, poor nutrition, penning, or handling. There is no scientific evidence about teratogenic or foetotoxic effects.

Can Albendazole + Oxyclozanide Oral Suspension interact with other drugs?

There is not enough information about the safety and efficacy of this drug when used with other veterinary medicinal products. The veterinarian should perform a thorough exam before including this product for treatment purposes.

How does Albendazole + Oxyclozanide Oral Suspension help in cases of Fasciola hepatica?

This disease is a widespread endoparasite. Studies show that with an effective therapeutic dose, this disease can be eliminated successfully after 5 days of treatment, and no fascioliasis and larvae will be detected in feces.

This drug can prevent anemia, submandibular edema, decreased weight gain, and decreased milk production.

Is only Albendazole + Oxyclozanide Oral Suspension enough to treat Fasciola hepatica?

The treatment process of this disease includes fluke removal in infected animals, and excluding the affected animals from snail-infested pastures. The timing of the treatment is important because it will result in optimal removal of flukes.

Is Albendazole + Oxyclozanide Oral Suspension effective for external parasites?

No, this drug is mainly used for treating endoparasitic infections. Consult with a veterinary professional to decide about the treatment process in cases of external parasites.

How does Albendazole + Oxyclozanide Oral Suspension help in the treatment process of Moniezia?

Studies show that during the grazing season, despite a rapid and repeated increase in infection rates, the use of albendazole resulted in zero ovoscopic findings and reduced prevalence in the second and third years of our study. Cases of monieziosis in cattle were nearly sporadic, and albendazole administered at 7.5 mg per 1 kg of body weight proved 100% effective when given individually as a suspension. When administered through medicated feeds, mass application did not consistently ensure all animals received therapeutic doses. Monieziosis is a health challenge and Albendazole may be considered the preferred treatment.

Is Albendazole + Oxyclozanide Oral Suspension effective against other parasitic infections besides Fasciola and Moniezia?

Yes, this drug is effective for various parasitic infections depending on the sensitivity of the parasite. Studies show that monospecific and mixed infections of Haemonchus contortus, Nematodirus spathiger, and Dictyocaulus filaria from sheep can be treated with this antiparasitic drug.

How should Albendazole + Oxyclozanide Oral Suspension be stored?

This medication should be stored in a dark, dry location under 30°C. Keep the bottle tightly sealed when not in use.

Is there a withdrawal period after treatment with Albendazole + Oxyclozanide?

The withdrawal time is 8-14 days for meat and 3-5 days for milk. The exact duration will depend on local regulations.

How much Albendazole + Oxyclozanide should be given to livestock?

The maximum dosage is 33ml/100kg of body weight in cattle and 10ml/30 kg of body weight in sheep and goats.

Refer to a veterinary doctor or pharmacist for guidelines on dosage.

As with all pharmaceuticals, some unwanted effects can occur from the use of Albendazole + Oxyclozanide Oral Suspension.

Some common side effects may include but are not limited to changes in stool consistency.

The side effects of this drug might also include loosening of feces, diarrhea, inappetence, and weight loss. If owners notice any side effects, they should report it to a veterinarian.

For a comprehensive list of all possible side effects of this medication, consult a veterinarian.

There are known interactions between Albendazole and other drugs, including cimetidine, dexamethasone, and praziquantel.

Always wash hands thoroughly after handling this product. Pregnant women should not handle Albendazole products, as it can be absorbed through direct skin contact. Those who handle this product should wear impermeable rubber gloves. Operators should not smoke, eat, or drink while handling this product. Contaminated clothing should be removed immediately.

This drug should not be used for an extended period because it might lead to resistance and result in ineffective therapy.

If an ineffective treatment is suspected, a fecal egg count reduction test needs to be performed. According to the results, an appropriate drug should be chosen.

Ruminant Animals Parasitic Infections

This drug is used for treating infections caused by the adult stage of Fasciola hepatica. It is also used for eliminating gravid tapeworm segments (Moniezia spp.).

Pig Parasitic Infections

This drug is effective in treating roundworms, tapeworms, and flukes. Treating lungworms with this drug can also be successful.