Paracetamol + Diclofenac Injection

Active Ingredients: Paracetamol, Diclofenac

Paracetamol + Diclofenac Injection is a combination analgesic and anti-inflammatory drug used to relieve pain, reduce inflammation, and control fever in horses and livestock animals like camels, cows, goats, sheep, and pigs. This drug is intended for administration by intramuscular injection only.

As an NSAID, diclofenac displays analgesic, anti-inflammatory, and antipyretic properties. Though the exact mechanism of action is not known, it is known to inhibit cyclooxygenase (COX-1 and COX-2).

Paracetamol (acetaminophen) shows a strong ability for pain management but exhibits weak anti-inflammatory activity. Though the exact site of action is unclear, it is thought to work by either inhibiting prostaglandin synthesis or activating descending serotonergic pathways.

The paracetamol and diclofenac combination is especially beneficial for its synergistic effect. Paracetamol's action provides pain relief without significant anti-inflammatory effects, making it ideal for managing moderate pain. Diclofenac reduces inflammation and pain associated with tissue damage and inflammatory conditions. Together, they offer a broader spectrum of pain control, making it effective for conditions in livestock where both pain and inflammation are present.

Paracetamol is generally well-tolerated, but it can be toxic at high doses, especially in cats and certain dog breeds. Diclofenac may pose risks of gastrointestinal upset, renal impairment, or hepatic dysfunction, particularly with long-term use. For these reasons, veterinary supervision is important for determining the appropriate dosing regimen and duration of therapy.

AdvaCare Pharma is a GMP-certified manufacturer and exporter of Paracetamol + Diclofenac Injections. We offer a wide range of high-quality and cost-effective veterinary medications that are available for distribution. These medications have been produced in our facilities in China, India, and the USA.

Paracetamol + Diclofenac Injection is manufactured and globally distributed by AdvaCare Pharma, a leading manufacturer of veterinary injections in the pharmaceutical industry. We have been committed to distributing high-quality, GMP-certified veterinary medications for the global market over the past 20 years. As a top Paracetamol + Diclofenac manufacturer, we ensure that all of our 100+ veterinary injections surpass our distributors' requirements by conducting routine internal and third-party facility audits.

What is Paracetamol + Diclofenac used for?

It's used to reduce pain and inflammation and control fever in post-operative recovery, musculoskeletal injuries, and various disorders. This combination provides a comprehensive approach managing pain by addressing both the discomfort experienced by the animal and the underlying inflammatory processes.

What animals can be treated with Paracetamol + Diclofenac Injection?

It is recommended for horses and livestock animals, including camels, cows, goats, sheep, and pigs.

How is a Paracetamol + Diclofenac Injection used?

This medication has been manufactured as a liquid, which is packaged in a vial. It is intended to be administered by intramuscular injection.

How does the combination of Paracetamol + Diclofenac work in animals?

Paracetamol offers effective analgesia by inhibiting pain signals in the brain and reducing fever by regulating body temperature. Diclofenac as an NSAID works by suppressing the production of inflammatory mediators. Together, they provide relief by addressing both the pain sensation and the underlying inflammatory processes, resulting in improved comfort and well-being for animals with various painful and inflammatory conditions.

Can Paracetamol + Diclofenac Injection be used for post-operative pain control in animals after surgery?

Yes, it can be used for post-operative pain control in animals. Veterinarians often include it as part of a comprehensive pain management plan to ensure the comfort of animals recovering from surgical procedures.

Is there a specific time of day when the drug should be administered?

It can be administered at any time of the day, but it should be given at approximately the same time each day to maintain consistent blood levels of the medication.

What is the onset of action of Paracetamol + Diclofenac Injection?

The onset of action can depend on factors such as the animal's condition and the route of administration. In some cases, noticeable pain relief and reduction in inflammation may occur within hours of administration, while the full effect may take up to 24 hours to manifest.

Can the treatment duration with Paracetamol + Diclofenac Injection be extended beyond 3 days?

The duration of treatment should not exceed 3 consecutive days unless directed by a veterinarian. Prolonged use may increase the risk of adverse effects, including liver and kidney damage.

Is Paracetamol + Diclofenac Injection available over-the-counter, or is it only accessible through a prescription?

It is typically available only with a prescription from a licensed veterinarian and is not available for purchase over the counter.

Is there a specific age limit for animals to receive this injection?

Paracetamol + Diclofenac Injection can be used in animals of varying ages, but caution should be exercised in geriatric species, as they may have reduced organ function and tolerance.

Can Paracetamol + Diclofenac Injection be used for long-term or chronic conditions?

No, this drug is typically used for short-term treatment of acute conditions.

Are there any known contraindications for the use of Paracetamol + Diclofenac Injection in animals?

It should not be used in animals with known allergies or hypersensitivity to any of its ingredients. This drug is contraindicated for animals with a history of gastrointestinal ulcers or bleeding. Caution is advised when using it in pregnant or lactating animals, and it should not be administered concurrently with other NSAIDs.

Is Paracetamol + Diclofenac Injection available for over-the-counter purchase, or is it strictly by prescription?

The drug is typically available only with a prescription from a veterinarian. It is not available for over-the-counter purchase.

How should Paracetamol + Diclofenac Injection be stored?

This medication should be stored in a dark, dry location under 30°C. It should be tightly sealed to prevent exposure to light, extreme temperatures, or moisture.

How much Paracetamol + Diclofenac Injection should be given to livestock?

The usual dose is 0.05-0.1ml per kg of body weight, given IM once per day. The duration of treatment is 2-3 consecutive days.

Can Paracetamol + Diclofenac Injection be administered concurrently with food or should it be given on an empty stomach?

It can be given with or without food as it does not significantly affect its absorption or efficacy.

What should be done if a dose of Paracetamol + Diclofenac Injection is missed?

If a dose is missed, it should be administered as soon as possible, although it's essential to maintain the prescribed dosing interval. Do not double the dose to make up for missing the last one.

What should be done if accidental overdose of Paracetamol + Diclofenac Injection is suspected?

Seek immediate veterinary attention. Overdose can lead to severe adverse effects, including liver and kidney damage.

Refer to a veterinary doctor or pharmacist for guidelines on dosage.

As with all pharmaceuticals, some unwanted effects can occur from the use of Paracetamol + Diclofenac Injection.

Some common side effects may include but are not limited to gastrointestinal effects.

If any of the mentioned side effects manifest, discontinue the use of the medication and consult a veterinarian without delay. Treatment may involve discontinuing the medication, providing supportive care, and administering other medications to manage the observed adverse effects.

For a comprehensive list of all possible side effects of this medication, consult a veterinarian.

Treatment with this drug should be administered with caution if an animal: • has renal or hepatic insufficiencies.

High doses of this medicine are known to cause liver and kidney damage. Any unusual symptoms should be promptly reported to a veterinarian for assessment and appropriate action to safeguard the animal's well-being.