Cold Syrup

Active Ingredients: Dextromethorphan HBr, Guaifenesin, Phenylephrine HCl, Paracetamol

Cold Syrup (Dextromethorphan HBr, Guaifenesin, Phenylephrine HCl, Paracetamol) is a combination drug used for treating the common cold, flu, or allergies. This medicine helps relieve symptoms such as stuffy nose, coughing, congestion, and sneezing. This formulation is not used for coughing caused by respiratory conditions such as asthma or emphysema.

Cold&Flu Relief MAX™ also includes the pain reliever and antipyretic, Paracetamol (acetaminophen), which helps reduce fever and relieve headache and pain.

Paracetamol, included in the MAX™ version, is a widely used in reducing fever and alleviating pain associated with cold and flu symptoms. Due to its presence in many over-the-counter and prescription drugs, caution must be exercised to avoid exceeding the recommended daily dosage. Excessive intake can lead to liver damage. This is crucial for individuals with pre-existing liver conditions or those who consume alcohol regularly.

The combination of Dextromethorphan HBr and Guaifenesin addresses both the dry cough and the mucus production aspects of cold and flu symptoms. Dextromethorphan acts centrally in the brain to suppress the cough reflex, while Guaifenesin's role as an expectorant assists in loosening and thinning respiratory tract secretions to facilitate a more productive cough. This dual action can provide comprehensive relief from varying types of coughs associated with respiratory infections.

Phenylephrine HCl as a decongestant addresses nasal and sinus congestion. Phenylephrine's vasoconstrictive action reduces blood flow to nasal passages, decreasing swelling and congestion. Patients with hypertension or certain heart conditions should use this medication cautiously, as vasoconstrictors can potentially elevate blood pressure.

Patients taking certain antidepressants, specifically monoamine oxidase inhibitors (MAOIs), or those with thyroid disorders should consult their physician before using medications containing Phenylephrine.

Cold Syrup is a GMP-certified product that is exported by AdvaCare Pharma. Our manufacturing factories are located in China, India, and the USA, and our extensive catalog of medical supplies is available for global distribution.

AdvaCare Pharma is a reputable manufacturer of Cold Syrup, and other pharmaceutical syrups, with a presence in 65 countries. We have implemented a "vested supplier-distributor relationship" business model that differentiates us from other large-scale medical manufacturers, facilitating a closer partnership with our pharmaceutical distributors. With a range of more than 500 GMP-approved medicines, including 55+ treatments in oral liquid dosage form, we are a Cold Syrup manufacturer that doctors trust and patients rely on.

Cold&Flu Relief

Each 20ml: Dextromethorphan HBr: 20mg, Guaifenesin: 400mg, Phenylephrine HCl: 10mg

Cold&Flu Relief MAX

Each 20ml: Paracetamol: 650mg, Dextromethorphan HBr: 20mg, Guaifenesin: 400mg, Phenylephrine HCl: 10mg

What is Cold Syrup used for?

It is used to temporarily relieve symptoms caused by conditions like the cold or flu, such as sneezing, coughing, and nasal congestion.

How should Cold Syrup be used?

This medication is manufactured as a liquid to be taken orally.

What dose should be taken?

The usual dose is 20ml, every 6-8 hours as symptoms persist.

Refer to a doctor or pharmacist for guidelines on dosage. Do not exceed the advisable dosage. The dosage is based on medical condition, response to the treatment, age, and weight.

Is Cold Syrup suitable for children of all ages?

Cold Syrup is generally not recommended for very young children, particularly those under the age of 4 years, due to the risk of serious side effects. Always consult a pediatrician before giving this medication to a child.

Can Cold Syrup interact with other over-the-counter cold medications?

It may interact with other over-the-counter cold or flu medications, especially those that contain similar active ingredients. This can increase the risk of side effects. Talk to a doctor before taking this drug with others.

Can Cold Syrup be taken on an empty stomach?

Yes, it can, but taking it with food may help to reduce gastrointestinal discomfort, such as nausea, that some individuals might experience.

How long can one safely use Cold Syrup?

Cold Syrup should not be used for prolonged periods. If symptoms persist for more than a week, worsen, or are accompanied by a high fever, medical attention should be sought.

Is it safe to operate machinery or drive after taking Cold Syrup?

Since this medication may cause dizziness or drowsiness in some individuals, avoid driving or operating heavy machinery until its effect on the user known.

Can Cold Syrup affect blood pressure?

Phenylephrine, one of the active ingredients, may increase blood pressure. Patients with hypertension should use this syrup with caution and under medical supervision.

Should Cold Syrup be avoided in certain respiratory conditions?

Cold Syrup should not be used in individuals with chronic respiratory conditions like asthma or chronic obstructive pulmonary disease (COPD).

Can Cold Syrup be used for allergies?

Cold Syrup can help alleviate symptoms like sneezing and nasal congestion associated with allergies, but is mainly used for cold and flu symptoms.

Is Cold Syrup effective in treating sinus infections?

It can relieve some symptoms associated with sinus infections, such as congestion, but it does not treat the infection itself. Antibiotics are often required for bacterial sinus infections.

Is Cold Syrup effective in treating the underlying cause of a cold or flu?

This product is formulated to manage and relieve symptoms associated with the common cold, flu, or allergies and does not treat the underlying viral infection causing these. The common cold and flu are typically caused by viruses, and the body's immune system generally clears these infections. Cold Syrup helps provide symptomatic relief while the body's natural defenses work to eliminate the infection.

Can Cold Syrup be used if you have a cough with phlegm?

Yes, this product contains Guaifenesin, an expectorant that helps loosen phlegm, making it easier to cough up.

What is the role of Dextromethorphan in Cold Syrup?

Dextromethorphan acts as a cough suppressant. It works on the cough center in the brain to reduce the urge to cough, making it useful for dry, unproductive coughs.

Can Cold Syrup be taken alongside antibiotics?

It can generally be taken with antibiotics, but consult a doctor first, as interactions may depend on the specific antibiotic being used concurrently.

How does Cold Syrup interact with alcohol?

Alcohol can enhance its sedative effects, increasing the risk of dizziness or severe drowsiness.

Is it necessary to refrigerate Cold Syrup?

Cold Syrup does not typically require refrigeration. It should be stored at room temperature, away from light and moisture. Check the packaging for specific storage instructions.

As with all pharmaceuticals, some unwanted effects can occur from the use of Cold Syrup.

The formulation of Cold Syrup containing Paracetamol warrants caution, particularly regarding liver health. Overdosing on Paracetamol can cause acute liver failure, which may not present immediate symptoms. Users must follow the recommended dosage and avoid combining it with other Paracetamol-containing products.

Patients should also be aware of the risk of rebound congestion with prolonged use of decongestants like Phenylephrine, which can lead to chronic nasal congestion if used for more than a few days consecutively. This effect, known as rhinitis medicamentosa, can create a cycle of dependency on nasal decongestants.

Phenylephrine may also worsen certain conditions such as glaucoma, hyperthyroidism, and hypertension. Its vasoconstrictive properties might lead to elevated blood pressure and exacerbate these conditions.

For a comprehensive understanding of all potential side effects, consult a medical professional.

If any symptoms persist or worsen, or you notice any other symptoms, please call your doctor.

This product should not be used with other drugs that cause drowsiness, sedation, or respiratory issues, including opioids and anxiety medicines.

Do NOT use Cold Syrup to induce sleep in children. Drink more fluids while undergoing treatment with Cold Syrup to assist the expectorant action of Guaifenesin, helping to thin and loosen mucus in the airways. Patients with certain medical conditions, such as heart failure or kidney disease, should consult their doctor about appropriate fluid intake to avoid exacerbating their condition.

Consider the potential for overuse or misuse of Cold Syrup containing Dextromethorphan HBr. While effective as a cough suppressant, Dextromethorphan can be subject to abuse, leading to serious side effects such as severe drowsiness, increased heart rate, and altered mental states. Patients with a history of substance misuse should be particularly cautious.

Objective and self-reported evidence of dextromethorphan antitussive efficacy in children, aged 6–11 years, with acute cough due to the common cold

This study evaluated the antitussive effects of dextromethorphan hydrobromide (DXM) in children, and both objective and subjective measures were considered.

The study was designed as a multiple-dose, double-blind, placebo-controlled, randomized pilot clinical trial involving children aged 6–11 years with cough due to the common cold. Eligible participants underwent a run-in period where their coughs were monitored after receiving a sweet syrup dose. They were then randomly assigned to receive either DXM or a placebo over a 4-day period. Coughs were recorded during the initial 24 hours.

Analysis of data from 128 patients (67 patients DXM; 61 patients placebo) revealed that DXM reduced total coughs over 24 hours (the primary endpoint) and daytime cough frequency by 21.0% and 25.5%, respectively, compared to placebo.

The conclusion is that DXM has antitussive efficacy in children.